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Subcutaneous injection, delivering the peptide into the fatty layer just beneath the skin, is the most common route in both animal research and human practice

Many patients achieve their weight loss goals at 1.0 to 1.7 milligrams (10-17 units) and maintain that dose indefinitely rather than advancing to the maximum

Studies have also shown that GLP-1 receptor agonists reduce pro-inflammatory mediators such as IL-1 and TGF-, restore the balance of MMP-9 and TIMP-1, and prevent excessive degradation of the extracellular matrix

Semaglutide (also injected weekly) was associated with an average weight loss of around 11% after 24 to 68 weeks, with evidence suggesting the effect can persist for up to two years, based on 18 randomized controlled trials (27 949 participants)