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Next-generation agents include CagriSema (semaglutide + cagrilintide, NDA filed December 2025, showing 22.7% weight loss), retatrutide (triple GIP/GLP-1/glucagon agonist, 28.7% weight loss in Phase 3), and orforglipron (oral non-peptide GLP-1, submitted to FDA)

The result is reduced hunger, lower calorie intake, and meaningful weight reduction

There is also some evidence that tirzepatide affects gastric emptying less aggressively than semaglutide at equivalent therapeutic levels, though direct comparison data during exercise is limited

Pancreatic polypeptide: a unique model for vagal control of endocrine systems