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The landmark SURPASS clinical trial program, which established tirzepatide's efficacy for diabetes management, did not include erectile function as an outcome measure

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Initially, a single dose of 10 g/kg (absolute dose range 0.71.2 mg) was administered to six subjects (three with severe RI and three with ESRD) but, based on the frequency and severity of gastrointestinal adverse effects, the 10 g/kg dose was not considered a tolerable starting dose