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Effective drugs need to interfere with this replication process, shutting down the viruss ability to proliferate inside the host, said Hussin Rothan, a post-doctoral researcher at Georgia State and co-author of the study

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This article describes the relationship between TMAO and chronic kidney disease and the research progress of drugs targeted TMAO, providing a reference for the development of anti-chronic kidney disease drugs targeted TMAO

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Concurrently, STAT6 activation facilitates macrophage-to-myofibroblast trans-differentiation and amplifies M2 macrophage polarization, a subset known to secrete profibrotic mediators that exacerbate renal fibrogenesis (Tianhui et al., 2023)

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