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Rapid weight loss is one of the most significant indirect factors

For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]

So much of the experimentation with GLP-1s is happening outside traditional research models, careful clinical trials and even the health system

Sustained Results Most patients reach meaningful milestones within 36 months