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Main text Role of oxidative stress in ALS ALS is an adult-onset neurodegenerative disease, characterized by degeneration and loss of upper motor neurons (MNs) in the cerebral cortex and lower MNs in the brainstem and spinal cord [69], leading to progressive weakness of voluntary muscles, and death caused by a diaphragmatic failure within 25 years [70, 71]

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A healthy rate of weight loss on GLP-1s is about one to two pounds per week, with many people reaching five to ten percent of their starting body weight lost over three to six months