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This mechanism may be particularly relevant for patients who had significant insulin resistance before starting GLP-1 therapy
Answer: Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications that includes semaglutide (Wegovy, Ozempic, Rybelsus), tirzepatide (Zepbound, Mounjaro), liraglutide (Victoza, Saxenda), and orforglipron (Foundayo), have become increasingly popular for obesity treatment (Mehrtash, JAMA Intern Med 2025)
As she recalls,'Standing in front of the gamma counter, it was clear who was [taking] a placebo and who got the peptide.' Despite this, results from this trial took time to be published because several journals rejected the paper
Many users report that they were not warned about the possibility of permanent stomach paralysis or the potential need for feeding tubes or surgeries to manage complications
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