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[42] Subsequent analyses have clarified that this early worsening of pre-existing retinopathy is a secondary effect caused by the rapid and robust drop in blood glucose levels, rather than a direct toxic effect of semaglutide on the eyes

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Demographic and Tumor Characteristics of Patients in the Literature We reviewed 63 patients reported in the literature with a mean age of 43 years (SD 12.4 years)

Rapid glycemic improvement can transiently worsen retinopathy