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We estimated the percent mediation of the change in eGFR at week 104, potentially attributable to change in weight, by assessing how much the treatment effect on eGFR was altered by including the weight change in the regression model adjusted for baseline eGFR and baseline weight

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These findings support the rationale for dual SGLT1/SGLT2 inhibition as a potential therapeutic strategy ( 3.2 Complications and side effects of SGLT2 inhibitors The most common side effect of SGLT-2 inhibitors is polyuria, resulting from osmotic diuresis