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Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]

Aspicam (Meloxicam) is a COX-2 preferential non-steroidal anti-inflammatory drug indicated for symptomatic relief of pain and inflammation in OA and RA, as per its approved prescribing information