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Finally, a publication bias toward studies reporting positive or synergistic effects between GLP-1RAs and exercise may inflate perceived efficacy

These studies looked at GLP1-RAs in those with obesity and other comorbidities, without T2D, at weight loss doses

We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig

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