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Preclinical evidence shows spinal GLP-1R activation attenuates bone cancer-induced allodynia via -endorphin release [24]

However, the study also revealed some alarming side effects: -Doubling of pancreatitis risk: Pancreatitis, or inflammation of the pancreas, can lead to complications like sepsis, organ failure and internal bleeding

20 Moreover, the high amount of visceral fat and epicardial adipose tissue (EAT), as well as associated plasma volume expansion, in obese individuals results in significant haemodynamic impairment at rest and during exercise, exerting local effects on the heart

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