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doi: 10.1161/circresaha.123.321872, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 48

Despite decades of research and numerous clinical trials, not a single disease-modifying therapy has been approved for osteoarthritis

By October 2024, the blockbuster drug tirzepatide had transformed Lilly into the most valuable drug company in the world

Minimal progress adjustments: If showing some improvement but less than hoped, consider increasing dose 25-50% (200mcg to 300mcg BPC-157, 2mg to 3-4mg TB-500)