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Reduced serotonergic signaling is closely associated with the onset of depressive symptoms, as it disrupts mood regulation and emotional processing

revised March 2025

Transactivation of c-Ret EHMES-1 cells were cultured in a 12-well plate until they were 80%90% confluent

However, while young senescent cells can protect organisms from cancer, but with the passage of time, the aging cells can evade the immune system and accumulation in the organization, secretion of proinflammatory cytokines, growth factors and protease, which establish a microenvironment that promote cancer (155) ( Figure 6 )