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The process of thyroid hormone production When the pituitary produces TSH, this sends the signal to the thyroid gland to produce mostly thyroxine T4 which is the inactive form

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As described in the results section, the animals included in the experimental design, including the non-androgenized controls, were fed a high-fat diet with 58% kcal from fat, 25.5% from carbohydrates, and 16.4% from proteins (Research Diets, D12331)

Unlike regular IGF-1, IGF-1 LR3 has an extended half-life, which prevents rapid degradation and allows it to remain active in the body longer (4)