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Overall, anti-IL-12/23 and anti-IL-23 agents provide an effective new option for moderate-to-severe IBD in patients who fail or are intolerant to anti-TNF therapy, and future generations of anti-IL drugs targeting finer subunits or downstream signaling will further promote precision and personalized treatment

In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs

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Effects of semaglutide on albuminuria and kidney function in people with overweight or obesity with or without type 2 diabetes: Exploratory analysis from the STEP 1, 2, and 3 trials