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Begin with a comprehensive thyroid workup, optimize hormone therapy, and introduce GLP-1s gradually if appropriate.

Treatment These medications are administered via injections, which can be administered in-office or at home with proper instruction

It's important to note that feeling cold is not listed as an official side effect in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), and evidence for this effect is largely anecdotal from patient reports and clinical observations

737 The level of GSH in MCAO/R mice decreases with the increase of lipid peroxidation