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These findings align with our plasma biomarker analyses demonstrating reduced plasma levels of the cytokines tumour necrosis factor and MCP-1 in CNS GIPR KO mice, as well as existing literature showing that GLP-1R agonists targeted to CNS GLP-1R have anti-inflammatory effects 20

Relation to Neuroprotection: Such synthetic substances bind to GLP-1 receptors in the cortex, hippocampus, amygdala, and basal ganglia, triggering the following signal transduction: Switching off inflammatory NF-B downstream pathways like cytokines (IL-1/IL-6) and tumor necrosis factor (TNF-)

These effects are typically mild initially, as starting doses (0.25 mg weekly for both Ozempic and Wegovy) are intentionally low to allow your body to adjust

Nemlig er det den mest konsentrerte intracellulre antioksidanten menneskekroppen produserer