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on euthyroid patients with Hashimotos disease showed that markers of oxidative stress (evaluated through advanced glycation end-products - AGEs) were significantly higher in patients compared to controls, and the activity of the enzymes glutathione peroxidase and thioredoxin reductase, as well as plasma antioxidant activity, was reduced in the patients compared to controls

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Looking ahead, further research is needed to determine long-term outcomes, refine patient selection criteria, and develop strategies to improve affordability and access

The specific mechanisms are as follows