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and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals

Firstly, there is no need to panic

It can be associated with: A sudden change in diet A diet with not enough fibre Not drinking enough fluid Loss of 'tone' of the bowel muscles in older people Pregnancy Medicines such as morphine or codeine Having to stay in bed for a long time Lack of exercise Whatever the cause, constipation can be uncomfortable

Unfortunately, making pauses during the cycle isnt so beneficial and may be an option for people with particular medical conditions