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While efforts are well-intentioned, many people overestimate their risk or underestimate their supplemental doses, which can cause added symptoms such as headaches, nausea, vomiting, diarrhea, itching and skin rashes

ABHD5 ligands that release ABHD5 from PLIN1 or PLIN5 independent of PKA activation, led to the discovery of long-chain acyl-CoA (LC-CoA) as an endogenous allosteric regulator of ABHD5 that promotes the interaction with PLIN1/5 (48)

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Wrapping your arm under compression, especially early on, also helps reduce inflammation, notes Dr