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Role in Growth and Development It plays a vital role in growth and development, as it promotes: Cell proliferation 19 Organ growth 20 Tissue differentiation 19 Bone growth and remodelling 21 Brain development 22 Neuroplasticity 22 It is particularly important during childhood and adolescence, when growth and development occur most rapidly

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Male Wistar/ST rats (10-week-old for in vivo experiments and 6- to 8-week-old for cell isolation) were purchased from Japan SLC (Shizuoka, Japan)