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SCFAs also stimulate the development of regulatory T cells (Tregs), which are critical for immunological tolerance and limiting excessive inflammation

This trial design was intended to improve trial enrollment and compliance with the protocol, as focus group discussions with parents of eligible children indicated significant reluctance to enroll in a trial of a licensed drug in which there was a 50% chance of receiving only placebo

Importantly, a meta-analysis of 14 clinical trials evaluating gastrointestinal adverse effects of GLP-1RAs found that long-acting agents had lower rates of nausea and vomiting than short-acting formulations

Novel triple mechanism means less predictability of long-term safety