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Documented effects in published research include collagen and elastin synthesis stimulation, fibroblast activity modulation, gene expression changes related to anti-inflammation and tissue repair, antioxidant pathway activation, and effects on hair follicle stem cells

The release date was delayed several times in 1998 before the game was finally released in November of that year in North America and Europe

Structural characterization of the DNA binding mechanism of retinoic acid-related orphan receptor gamma