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Passive targeting of tumors relies on the EPR effect in leaky tumor blood vessels, which allows nanoparticles to enter and remain in the tumor interstitial sites [81]

Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories

10.1016/j.nantod.2024.102241 Nano Today

Central nausea signaling: GLP-1 receptors in the area postrema (the brain's vomiting center) are activated by circulating drug, producing nausea independently of gastric effects