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Furthermore, NAD levels in the brain are essential for maintaining central nervous system (CNS) vascular integrity, due to NAD maintaining an energy supply that plays crucial roles in cell survival, such as having a protective factor in cerebral ischemia, since its disorder leads to energy depletion (, )

For example, Gilot et al

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Serum and Cerebrospinal Fluid Concentrations of Homoarginine, Arginine, Asymmetric and Symmetric Dimethylarginine, Nitrite and Nitrate in Patients With Multiple Sclerosis and Neuromyelitis Optica