Endogenous IGF-1 circulates bound to IGFBP-3 in a ternary complex with the acid-labile subunit, restricting bioavailability to less than 1% of total circulating IGF-1
Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA
Shao Y, Zhang H, Shi Q, Wang Y, Liang Q
Additionally, hedysarum polysaccharide, derived from Radix Hedysari , ameliorated DPN by activating the Keap1/Nrf2 signaling pathway, further supporting the role of Nrf2 activation in managing OS-related complications in diabetes (He et al., 2022)