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Retatrutide works by activating three hormone receptors simultaneously: GLP-1 (reduces appetite and slows digestion), GIP (improves insulin sensitivity and fat distribution), and glucagon (increases energy expenditure and fat breakdown)

10.3390/ANTIOX12081600 [DOI] [PMC free article] [PubMed] [Google Scholar] Negi G, Kumar A, Sharma SS (2011) Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-B and Nrf2 cascades

For the best results, Wegovy is most effective when combined with a moderately reduced-calorie diet, increased physical activity, and consistent monitoring

pharmacies and may be offered via telehealth or in-office visits