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The same ACTB (p.Ser348Leu) variant was reported in six individuals in the literature

Figure 1 We validated the model extensively against reported experimental data (not used to construct the model) on how enzyme and transporter activities and metabolite concentrations change in response to stimulation ( Presentation 1: Supplementary Figure S1 , Presentation 1: Full Annex - Supplementary Table S1 )

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The earliest signs that semaglutide is working often include reduced appetite, feeling full sooner, fewer cravings, and less interest in snacking