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Unlike the heart, the lungs are directly exposed to a variety of environmental irritants that can trigger the destruction of normal ECM structure and its substitution by excessive scar tissue (e.g., interstitial lung disease- ILD) or a protracted dismantling of pulmonary airways and alveoli (emphysema in COPD)

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The rationale for this grouping is that, despite potential dilution from including OSA free individuals in the control group, the high estimated prevalence of OSA among T2D - together with the higher baseline risk associated with T2D-OSA comorbidity - should allow any clinically relevant associations of CPAP to be detected