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eClinical Medicine

A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)

Others showed that both GLP-1 and DPP-4i limit infarct size in animal models of MI by increasing intracellular cAMP levels and activating PKA (51, 52)