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Despite the high levels of iron present, GO fibroblasts resist ferroptosis due to robust antioxidant defenses, particularly the elevated activity of GPX4 and NRF2 (nuclear factor erythroid 2related factor 2)

Burckhardt, B

Nausea, mild abdominal discomfort, and occasional vomiting are frequent, usually mild to moderate, and typically improve over several weeks as the body adjusts to the medication