retatrutide peptide vs tirzepatide Tirzepatide: July 2026 Comparison Retatrutide vs Tirzepatide vs Semaglutide

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Patients reduced 3-5% of their body weight after using it for 6 months

* **Serious Risks and Warnings:** Tirzepatide carries significant warnings: * **BOXED WARNING (Most Serious): Risk of Thyroid C-cell Tumors.** This is based on rodent studies showing Tirzepatide caused these tumors, including Medullary Thyroid Carcinoma (MTC)

The median duration of constipation was longer: 47 days in the semaglutide arm and 35 days for placebo, with the prevalence plateauing at approximately week 10 (Figure 2D)