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The formation of 5-methylTHF depends on N 5,10 -methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of N 5,10 -methylenetetrahydrofolate (5, 10-methyleneTHF) (Fig

Analysis of covariance for depression severity adjusted for baseline values at weeks 2, 4, 6 and 8 showed that the vitamin Dfluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment