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Mechanism of action Qsymia works through central nervous system stimulation

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This sulfonamide ( 41 ) demonstrates a high metabolic stability and alters dendritic spine morphology and increases spine density in primary cultures of hippocampal neurons ( Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Figure 10)

10.1186/1750-1172-1-16 Carelli V, Carbonelli M, de Coo IF, et al.: International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy