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Furthermore, low-grade inflammation of the endothelium is an early event in the pathogenesis of atherosclerotic cardiovascular disease and the GLP-1 analog liraglutide was shown to exhibited anti-oxidative and anti-inflammatory effects, including upregulation of anti-oxidative enzymes and inhibition of nuclear factor kappa B (NF-B)-signaling on endothelial cells (67, 77)

Niwa, A

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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction