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"A human protein-protein interaction network: a resource for annotating the proteome"

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

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The same body of work has identified outgrowth of the FAK-paxillin pathway, a signaling cascade involved in cell migration, as one plausible mechanism [Chang et al., 2011]