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& Keung, W

The following sections examine representative systemsapelin, spexin, meteorin-like protein (METRNL), and oxyntomodulinwith explicit attention to the evidence supporting their metabolic roles, the reasons for historical underexploration, and the translational questions that remain unresolved

The secretion of incretin hormones from enteroendocrine cells in the gut epithelium, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), potentiates postprandial insulin secretion, a phenomenon known as the incretin effect

DMT1 is a key protein regulating iron balance, and DMT1 inhibitors have been reported to selectively target CSCs in primary cancer cells and circulating cancer cells, causing ferroptosis in breast cancer CSCs and reversing multidrug resistance through lysosomal iron accumulation and ROS production