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In contrast, inhibition of ALK1/2/3/6 blocked the induction of CTGF and COL1A1 ( COL1A1 and CTGF is conveyed via ALK1/Smad1/5- and also ERK1/2-signal pathways rather than ALK5/Smad2/3-activation ( In cells from articular cartilage, synovial tissue and fluid from patients with OA, elevated levels of the transcription factor hypoxia inducible factor (HIF)-1 were found, indicating hypoxic conditions, that are associated with progressive joint damage ( VEGFA ), TGFB , insulin-like growth factor 2 ( IGF2 ), collagen type 2 alpha 1 ( COL2A1 ), and aggrecan ( ACAN )
The majority of the population is deficient in Vitamin D3 and they dont even realize it
Acknowledgements Professor Marcus Maurer for some of his thoughts on CSU and its aetiology
GHK-Cu collagen levels decline as we age
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