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Neurodegenerative diseases such as Alzheimers: The creation of amyloid-beta, which builds up in plaques in Alzheimers sufferers brains, requires the O-glycosylation of the amyloid precursor protein

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Synonyms: 5-Amino-1MQ, NNMT Inhibitor

In rodent models, behavioral hyperactivity, stereotypy (repetitive non-functional movements), hyperthermia, and muscle rigidity are the primary indicators