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Mechanistically, liraglutide administration inhibited the upregulation of pain-related markers in the TNC, including calcitonin gene-related peptide (CGRP), c-fos, and components of the PI3K/Akt signaling pathway [94]

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The aim of this narrative review is to explore the current evidence on the renoprotective effects of GLP1-RAs, with a particular focus on their effects on albuminuria, and to discuss strategies for individualized implementation of these agents in the management of diabetic nephropathy