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In conclusion, PXN showed greater improvements in cognition and BDNF levels compared to CAF, further substantiating PXN as a nootropic with greater benefits compared to CAF

A randomized controlled trial found that when hypertensive patients taking beta-blockers were given melatonin supplements, their sleep quality improved, confirming the connection between these drugs and lower melatonin levels (Scheer et al., 2012)