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Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus

People with this chronic, progressive neurological disorder have high levels of oxidative stress and premature cellular die off in a part of the brain called the substantia nigra

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To detect immune cell populations, cells were stained with the following antibodies: an APC/Cyanine7-conjugated anti-mouse CD45 antibody (#103116, BioLegend), a PerCP/Cyanine5.5-conjugated anti-mouse CD3 antibody (#100328, BioLegend), a PerCP/ Cyanine5.5-conjugated anti-mouse/human B220 antibody (#103236, BioLegend), a FITC-conjugated anti-mouse I-A/I-E antibody (#553623, BD Biosciences), a PE-conjugated anti-mouse CCR3 antibody (#144506, BioLegend), a PE/Cyanine7-conjugated anti-mouse CD11c antibody (#117318, BioLegend), and a Brilliant Violet 421-conjugated anti-mouse F4/80 antibody (#123132, BioLegend)