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Abstract Dipeptidyl peptidase-4 (DPP-4) is an important protease that is widely expressed on the surface of human cells and plays a key role in immune-regulation, inflammation, oxidative stress, cell adhesion, and apoptosis by targeting different substrates

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These preclinical findings triggered regulatory caution: the FDA is not recommended during pregnancy

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Hence, weight loss with a focus on reducing central adiposity is one of the main priorities in management of diabetes

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