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Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress

Semaglutide, on the other hand, is much more expensive due to there being no generic options

Author disclaimer The views expressed are those of the authors and do not necessarily reflect those of the Amsterdam UMC location AMC

In strict plant-based diets intake is usually lower, so it is advisable to monitor overall nutrient intake, including the muscle mineral balance during periods of high physical demand