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6.3 Immune dysregulation For decades, immune cells and cytokines have been associated with human hypertension, but recent advances in immunological tools and animal models have allowed detailed examination of their roles in various experimental models

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The combined inflammatory impact of cytotoxicity by CD8+ T cells, immune-mediated perturbations of the islet ECM, and other mechanistic changes lead to cell death and decreased cell mass in a time-dependent manner ( Figure 2 )

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