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2 Tumor-associated macrophages: an in-depth analysis The traditional belief that tumor-associated macrophages (TAMs) solely originate from bone marrow monocytic progenitors has evolved substantially in recent years ( 2.1 Diversity and classifications of TAM The diverse origins and functional variability of TAMs ( Figure 2 ) pose considerable difficulties for their ontological classification ( Figure 2 2.2 Macrophage polarization states and their distinctive properties Macrophages exhibit remarkable heterogeneity and adaptability, rapidly responding to environmental cues by polarizing into functionally distinct phenotypes

Although the results could not be replicated by others, 180 15 years later Joseph Weiss 181 was able to achieve significant tumor growth inhibition in 20 out of 90 incurable cancer patients with a similar method

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Requests to access the datasets should be directed to Ana Maria Castejon, [email protected].