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The influence on the BPC-157 dopamine system, in particular, may explain some of the behavioral effects observed in animal studies, including antidepressant-like and anxiolytic-like activities

Further mediation analysis via two-step MR showed that this effect was partly mediated through reduced T2D, obesity, hypertension and cardiovascular disease (CVD), with mediated proportions of 2.89% (95% CI: 1.28% to 4.49%), 6.83% (95% CI: 2.25% to 11.41%), 3.22% (95% CI: 1.21% to 5.23%), and 3.06% (95% CI: 0.51% to 5.62%), respectively

If nausea is bothersome, eating smaller, more frequent meals and avoiding high-fat foods can help

In December 2022, the FDA expanded Wegovy's indication to include adolescents aged 12 years and older with obesity