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Titration : After four weeks, the dose is usually increased to 0.5 mg once weekly

Facial drooping or sagging refers to the loss of firmness and elasticity in the facial skin and tissues, resulting in a noticeably more aged and hollowed appearance

(PubMed) There is also a more basic issue: even when these studies report health or survival benefits, they do not establish that the benefit was driven specifically by telomere extension