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N Engl J Med 2010;362:1575-85.ArticlePubMedPMC 599

Mol Microbiol 111:918937

137(3):327-31 Sinaii N, Plumb K et al

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy